Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase

Dear Editor, The cryptochrome （CRY） flavoproteins are criti cal components of the mammalian molecular circa dian clock, which operates through an auto-regulatory transcription-translation feedback loop [1]. In this clockwork, a pair of transcription factors, CLOCK and BMAL1, drive the expression of...

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Bibliographic Details
Published inCell research Vol. 23; no. 12; pp. 1417 - 1419
Main Authors Nangle, Shannon, Xing, Weiman, Zheng, Ning
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.12.2013
Nature Publishing Group
Subjects
631/45/612/1225
631/535
631/80/474/2073
Animals
Binding Sites
Biomedical and Life Sciences
Carbazoles - chemistry
Carbazoles - metabolism
Cell Biology
Cryptochromes - chemistry
Cryptochromes - metabolism
Crystallography, X-Ray
F-Box Proteins - chemistry
F-Box Proteins - metabolism
Flavin-Adenine Dinucleotide - chemistry
Flavin-Adenine Dinucleotide - metabolism
Letter to the Editor
Life Sciences
Mice
Models, Molecular
Protein Binding
Protein Structure, Tertiary
Sulfonamides - chemistry
Sulfonamides - metabolism
Ubiquitin-Protein Ligases - chemistry
Ubiquitin-Protein Ligases - metabolism
哺乳动物
小分子
晶体结构
泛素连接酶
竞争
转录因子
隐花色素
黄素蛋白
Online AccessGet full text
ISSN1001-0602
1748-7838
1748-7838
DOI10.1038/cr.2013.136

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Summary:Dear Editor, The cryptochrome （CRY） flavoproteins are criti cal components of the mammalian molecular circa dian clock, which operates through an auto-regulatory transcription-translation feedback loop [1]. In this clockwork, a pair of transcription factors, CLOCK and BMAL1, drive the expression of CRYs, Periods （PERs）, and other clock-controlled genes, while CRYs and PERs heterodimerize and repress their own gene expression by inhibiting CLOCK-BMALl-mediated transcription [2, 3]. To establish rhythmic protein oscillation, CRYs are ubiq- uitinated by the SCF^FBXL3 ubiquitin ligase and targeted for rapid proteasomal degradation [4-6].
Bibliography:31-1568/Q
Dear Editor, The cryptochrome （CRY） flavoproteins are criti cal components of the mammalian molecular circa dian clock, which operates through an auto-regulatory transcription-translation feedback loop [1]. In this clockwork, a pair of transcription factors, CLOCK and BMAL1, drive the expression of CRYs, Periods （PERs）, and other clock-controlled genes, while CRYs and PERs heterodimerize and repress their own gene expression by inhibiting CLOCK-BMALl-mediated transcription [2, 3]. To establish rhythmic protein oscillation, CRYs are ubiq- uitinated by the SCF^FBXL3 ubiquitin ligase and targeted for rapid proteasomal degradation [4-6].
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These two authors contributed equally to this work.
ISSN:1001-0602
1748-7838
1748-7838
DOI:10.1038/cr.2013.136