Rectal and Vaginal Eradication of Streptococcus agalactiae (GBS) in Pregnant Women by Using Lactobacillus salivarius CECT 9145, A Target-specific Probiotic Strain

• Published in: Nutrients Vol. 11; no. 4; p. 810
• Main Authors: Martín, Virginia, Cárdenas, Nivia, Ocaña, Sara, Marín, María, Arroyo, Rebeca, Beltrán, David, Badiola, Carlos, Fernández, Leónides, Rodríguez, Juan M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.04.2019; MDPI
• Subjects: Adult; Antibiotics; Antiinfectives and antibacterials; Antimicrobial activity; Bacteriocins; Colonization; Epidemiology; Female; Food safety; GBS; Health care; Humans; Infections; Infectious diseases; Intestine; Lactation; Lactobacilli; Lactobacillus salivarius; Mastitis; Microbiomes; Microbiota; Microorganisms; Neonates; Oral administration; Organic acids; Pilot Projects; Pregnancy; Pregnancy Complications, Infectious - microbiology; Pregnancy Complications, Infectious - therapy; probiotic; Probiotics; Probiotics - therapeutic use; Rectum; Rectum - microbiology; Sepsis; Streptococcal Infections - microbiology; Streptococcal Infections - therapy; Streptococcus agalactiae; Streptococcus agalactiae - drug effects; Streptococcus infections; Treatment Outcome; Vagina; Vagina - microbiology; Womens health; United Kingdom > UK; France; United States > US; Spain; GBS; probiotic; Streptococcus agalactiae; Lactobacillus salivarius; pregnancy
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu11040810

(Group B Streptococci, GBS) can cause severe neonatal sepsis. The recto-vaginal GBS screening of pregnant women and intrapartum antibiotic prophylaxis (IAP) to positive ones is one of the main preventive options. However, such a strategy has some limitations and there is a need for alternative approaches. Initially, the vaginal microbiota of 30 non-pregnant and 24 pregnant women, including the assessment of GBS colonization, was studied. Among the isolates, 10 strains were selected for further characterization. In vitro characterization revealed that CECT 9145 was the best candidate for GBS eradication. Its efficacy to eradicate GBS from the intestinal and vaginal tracts of pregnant women was evaluated in a pilot trial involving 57 healthy pregnant women. All the volunteers in the probiotic group ( = 25) were GBS-positive and consumed ~9 log cfu of CECT 9145 daily from week 26 to week 38. At the end of the trial (week 38), 72% and 68% of the women in this group were GBS-negative in the rectal and vaginal samples, respectively. CECT 9145 seems to be an efficient method to reduce the number of GBS-positive women during pregnancy, decreasing the number of women receiving IAP during delivery.