Role of Oral and Gut Microbiota in Dietary Nitrate Metabolism and Its Impact on Sports Performance

• Published in: Nutrients Vol. 12; no. 12; p. 3611
• Main Authors: González-Soltero, Rocío, Bailén, María, de Lucas, Beatriz, Ramírez-Goercke, Maria Isabel, Pareja-Galeano, Helios, Larrosa, Mar
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.11.2020; MDPI
• Subjects: Anaerobic threshold; Athletic Performance - physiology; Bacteria; Bioavailability; Blood circulation; Blood pressure; Diet - methods; Dietary Supplements; Digestive system; Efficiency; Exercise; Gastrointestinal Microbiome - physiology; Homeostasis; Humans; Intestinal microflora; Metabolism; Metabolites; Microbiota; Microbiota - physiology; microbiota-muscle axis; Microorganisms; Mouth - microbiology; Muscles; Musculoskeletal system; nitrate supplementation; Nitrates; Nitrates - metabolism; Nitric oxide; nitrite metabolism; Oral cavity; Physical fitness; Respiration; Review; Skeletal muscle; Sports; sports performance; Veillonella; nitric oxide; microbiota-muscle axis; Veillonella; nitrate supplementation; sports performance; nitrite metabolism
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12123611

Nitrate supplementation is an effective, evidence-based dietary strategy for enhancing sports performance. The effects of dietary nitrate seem to be mediated by the ability of oral bacteria to reduce nitrate to nitrite, thus increasing the levels of nitrite in circulation that may be further reduced to nitric oxide in the body. The gut microbiota has been recently implicated in sports performance by improving muscle function through the supply of certain metabolites. In this line, skeletal muscle can also serve as a reservoir of nitrate. Here we review the bacteria of the oral cavity involved in the reduction of nitrate to nitrite and the possible changes induced by nitrite and their effect on gastrointestinal balance and gut microbiota homeostasis. The potential role of gut bacteria in the reduction of nitrate to nitrite and as a supplier of the signaling molecule nitric oxide to the blood circulation and muscles has not been explored in any great detail.