PKR stirs up inflammasomes

Inflammasomes are multiprotein complexes that detect and respond to foreign and endogenous danger signals by activating caspase-1; ac-tive caspase-1, in turn, matures the pro-inflammatory IL-β family cy-tokines by cleaving their pro-forms into the biologically active cytokines. The upstream mechanis...

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Bibliographic Details
Published inCell research Vol. 23; no. 2; pp. 168 - 170
Main Authors Stunden, H James, Latz, Eicke
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.02.2013
Nature Publishing Group
Subjects
631/250/256/2177
631/80/304
Animals
Biomedical and Life Sciences
Carrier Proteins - metabolism
Cell Biology
Humans
Inflammasomes - metabolism
Life Sciences
Nitric Oxide - metabolism
NLR Family, Pyrin Domain-Containing 3 Protein
PKR
Research Highlight
Shock, Septic - prevention & control
Upstream
内源性
复合物
成熟
激活
生物活性
细胞因子
蛋白激酶
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Summary:Inflammasomes are multiprotein complexes that detect and respond to foreign and endogenous danger signals by activating caspase-1; ac-tive caspase-1, in turn, matures the pro-inflammatory IL-β family cy-tokines by cleaving their pro-forms into the biologically active cytokines. The upstream mechanisms leading to inflammasome activation, in par- ticular for the NRLP3 inflammasome, remain poorly understood. Lu and colleagues identify a new function of Protein Kinase R （PKR） for activat-ing the NLRP1, NLRP3, NLRC4 and AIM2 inflammasomes, thus identify-ing a potential new target for treating inflammasome-mediated diseases.
Bibliography:H James Stunden, Eicke Latz（1 Institute of lnnate Immunity, Biomedical Center, University Hospitals Bonn, Sigmund-Freud-Str. 25, Bonn 53127, Germany; 2 University of Mas-sachusetts Medical School, Division of Infec-tious Diseases ＆ Immunology, 364 Plantation Street LRB 370M, Worcester, MA 01605, USA; 3 Deutsches Zentrum fur Neurodegenerative Er-krankungen （DZNE）, Sigmund-Freud-Str. 25, Bonn 53127, Germany）
31-1568/Q
Inflammasomes are multiprotein complexes that detect and respond to foreign and endogenous danger signals by activating caspase-1; ac-tive caspase-1, in turn, matures the pro-inflammatory IL-β family cy-tokines by cleaving their pro-forms into the biologically active cytokines. The upstream mechanisms leading to inflammasome activation, in par- ticular for the NRLP3 inflammasome, remain poorly understood. Lu and colleagues identify a new function of Protein Kinase R （PKR） for activat-ing the NLRP1, NLRP3, NLRC4 and AIM2 inflammasomes, thus identify-ing a potential new target for treating inflammasome-mediated diseases.
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ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2012.125