Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma

• Published in: Clinical ophthalmology (Auckland, N.Z.) Vol. 4; no. default; pp. 643 - 647
• Main Authors: Nomura, Yuya, Nakakura, Shunsuke, Moriwaki, Mitsuyasu, Takahashi, Yasuhiro, Shiraki, Kunihiko
• Format: Journal Article
• Language: English
• Published: New Zealand Taylor & Francis Ltd 01.01.2010; Dove Press; Dove Medical Press
• Subjects: 24-hour intraocular pressure; fluctuation; Glaucoma; normal tension glaucoma; Ophthalmology; Original Research; Travatan Z; travoprost; travoprost; normal tension glaucoma; 24-hour intraocular pressure; fluctuation; Travatan Z
• ISSN: 1177-5483; 1177-5467; 1177-5483
• DOI: 10.2147/OPTH.S10521

The effect of travoprost 0.004% on 24-hour intraocular pressure (IOP) was examined in patients with normal tension glaucoma (NTG). This study included 17 patients with newly diagnosed unilateral NTG. IOP was measured at three-hour intervals over 24 hours by Goldman applanation tonometer in patients taking topical travoprost 0.004% and was compared retrospectively with 24-hour IOP data in untreated eyes. IOP values were significantly reduced at individual time points after treatment (P < 0.01). Mean 24-hour IOP, maximum 24-hour IOP, minimum 24-hour IOP, and 24-hour IOP fluctuations at baseline (mean +/- SD) were 12.9 +/- 2.2 mmHg, 15.4 +/- 2.7 mmHg, 10.5 +/- 2.2 mmHg, and 4.9 +/- 1.2 mmHg, respectively, and were significantly reduced to 10.3 +/- 2.0 mmHg, 12.4 +/- 2.5 mmHg, 8.5 +/- 1.9 mmHg (all P < 0.001), and 3.9 +/- 1.5 mmHg (P < 0.05), respectively, after treatment. The rate of IOP reduction greater than 20% was 58.8% (10 eyes) for maximum 24-hour IOP and 53.0% (nine eyes) for mean 24-hour IOP. Travoprost reduced IOP throughout the 24-hour study period, with over half of the eyes examined showing IOP reduction exceeding 20%.