The interaction between energy intake, physical activity and UCP2 -866G/A gene variation on weight gain and changes in adiposity: an Indonesian Nutrigenetic Cohort (INDOGENIC)

• Published in: British journal of nutrition Vol. 125; no. 6; pp. 611 - 617
• Main Authors: Muhammad, Harry Freitag Luglio, Sulistyoningrum, Dian Caturini, Huriyati, Emy, Lee, Yi Yi, Muda, Wan Abdul Manan Wan
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.03.2021
• Subjects: Adipose tissue; adiposity; Adults; Body fat; Body weight; Body weight gain; cohort studies; Correlation; Data collection; Deoxyribonucleic acid; Diet; DNA; Energy intake; Energy regulation; Exercise; Gene expression; genes; genotype; Genotype & phenotype; Genotypes; Indonesia; Influence; Lifestyles; Mitochondrial uncoupling protein 2; Molecular Nutrition; Nutrition research; Obesity; Physical activity; Physical fitness; Questionnaires; Variation; Weight control; weight gain; Indonesia; Energy intake; Obesity; Adiposity; Physical activity; Weight gain; UCP2
• ISSN: 0007-1145; 1475-2662; 1475-2662
• DOI: 10.1017/S0007114520003104

The present study aimed to investigate an interaction between energy intake, physical activity and UCP2 gene variation on weight gain and adiposity changes in Indonesian adults. This is a prospective cohort study conducted in 323 healthy adults living in the city of Yogyakarta, Indonesia. Energy intake, physical activity, body weight, BMI, percentage body fat and waist:hip ratio (WHR) were measured at baseline and after 2 years while UCP2 -866G/A gene variation was determined at baseline. We reported that after 2 years subjects had a significant increment in body weight, BMI, body fat and reduction in WHR (all P < 0·05). In all subjects, total energy intake was significantly correlated with changes in body weight (β = 0·128, P = 0·023) and body fat (β = 0·123, P = 0·030). Among subjects with the GG genotype, changes in energy intake were positively correlated with changes in body weight (β = 0·232, P = 0·016) and body fat (β = 0·201, P = 0·034). These correlations were insignificant among those with AA + GA genotypes (all P > 0·05). In summary, we show that UCP2 gene variation might influence the adiposity response towards changes in energy intake. Subjects with the GG genotype of UCP2 -866G/A gene were more responsive to energy intake, thus more prone to weight gain due to overeating.