Two New neo-Clerodane Diterpenes in Ajuga decumbens

Study on the chemical constituents of Ajuga decumbens resulted in the isolation of two new minor neo-clerodane diterpenes, ajugacumbins E and F, together with a known diterpene, ajugamarin and an iridoid, 8-acetyl-harpagide.By means of spectroscopic analysis, structures of the new diterpenes were de...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 38; no. 11; pp. 3167 - 3168
Main Authors MIN, Zhi-da, MIZUNO, Mizuo, WANG, Shi-qiang, IINUMA, Munekazu, TANAKA, Toshiyuki
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1990
Maruzen
Subjects
Ajuga decumbens
ajugacumbin E
ajugacumbin F
ajugamarin
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Labiatae
neo-clerodane diterpene
Other biological molecules
Terpenes, steroids. Hormones
Characterization
Iridoid
Terpenoid
Molecular structure
Labiatae
Dicotyledones
Angiospermae
Plant origin
Isolation
Spermatophyta
NMR spectrometry
Mass spectrometry
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Summary:Study on the chemical constituents of Ajuga decumbens resulted in the isolation of two new minor neo-clerodane diterpenes, ajugacumbins E and F, together with a known diterpene, ajugamarin and an iridoid, 8-acetyl-harpagide.By means of spectroscopic analysis, structures of the new diterpenes were determined to be 1α, 3α, 6α-triacetoxy-4, 7-expoxy 18α-(2'-hydroxy-3'-methylene-butyryloxy)-neo-cleroda-13-en-15, 16-olide for ajugacumbin E, and 4α, 6α-dihyeroxy-4β-hrdroxymethyl-18α-tigloyloxy-neo-cleroda-13-en-15, 16-olide for ajugacumbin F.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.38.3167