FGF7 protein expression in human breast carcinomas

• Published in: The Journal of pathology Vol. 186; no. 3; pp. 269 - 274
• Main Authors: Jacquemier, Jocelyne, Sun, Zhen-zhu, Penault-llorca, Frédérique, Geneix, Jeanine, Devilard, Elizabeth, Adélaïde, José, Birnbaum, Daniel
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.11.1998; Wiley
• Subjects: Antibodies, Monoclonal; Biological and medical sciences; Blotting, Western; breast cancer; Breast Neoplasms - chemistry; Breast Neoplasms - mortality; Carcinoma, Ductal, Breast - chemistry; Carcinoma, Ductal, Breast - mortality; cell-cell communication; Chi-Square Distribution; expression; Female; FGF7; fibroblast growth factor; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; growth factor; Growth Substances - analysis; Gynecology. Andrology. Obstetrics; Humans; Immunohistochemistry; keratinocyte growth factor; mammary gland; Mammary gland diseases; Medical sciences; stroma; Survival Rate; Tumors; tumourigenesis; Human; Immunohistochemistry; Fibroblast growth factor; Molecular form; Carcinoma; Cytokine; Stroma; Cell cell interaction; Malignant tumor; Gene expression; Carcinogenesis; Pathology; Mammary gland diseases; Polypeptide; Immunoblotting assay; Mammary gland; Molecular biology; Growth factor
• ISSN: 0022-3417; 1096-9896
• DOI: 10.1002/(SICI)1096-9896(1998110)186:3<269::AID-PATH187>3.0.CO;2-G

FGFs, especially FGF7, are thought to play an important role in the stroma–epithelium interactions that take place in several tissues, including the prostate and mammary glands. Using an immunohistochemistry approach, FGF7 protein expression was measured in a series of 80 human breast carcinomas. FGF7 was found to be expressed in two‐thirds of cases studied, either in the stroma or in the tumour cells. Although it did not reach significance level, a tendency was noted for FGF7 expression to be associated with the most differentiated and least aggressive tumours. Copyright © 1998 John Wiley & Sons, Ltd.