Asymmetric Reductive Amination by Combined Brønsted Acid and Transition-Metal Catalysis

The best of both worlds: A combination of organocatalysis and transition‐metal catalysis serve in the highly stereoselective and atom‐economical reductive amination of a broad range of ketones. A chiral Brønsted acid catalyst facilitates the formation of protonated imines in situ and serves as chira...

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Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 48; no. 39; pp. 7124 - 7125
Main Author Klussmann, Martin
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 14.09.2009
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
Acids - chemistry
Amination
asymmetric catalysis
Catalysis
Hydrogenation
Molecular Structure
organocatalysis
Oxidation-Reduction
Stereoisomerism
Transition Elements - chemistry
transition metals
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Summary:The best of both worlds: A combination of organocatalysis and transition‐metal catalysis serve in the highly stereoselective and atom‐economical reductive amination of a broad range of ketones. A chiral Brønsted acid catalyst facilitates the formation of protonated imines in situ and serves as chiral counteranion, while a chiral iridium complex catalyzes the reduction with elemental hydrogen.
Bibliography:http://dx.doi.org/10.1002/anie.200903765
ArticleID:ANIE200903765
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content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200903765