Allogeneic haematopoietic stem cell transplantation for the treatment of adult T‐cell leukaemia/lymphoma

• Published in: British journal of haematology Vol. 120; no. 2; pp. 304 - 309
• Main Authors: Kami, Masahiro, Hamaki, Tamae, Miyakoshi, Shigesaburo, Murashige, Naoko, Kanda, Yoshinobu, Tanosaki, Ryuji, Takaue, Yoichi, Taniguchi, Shuichi, Hirai, Hisamaru, Ozawa, Keiya, Kasai, Masaharu
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.01.2003; Blackwell; Blackwell Publishing Ltd
• Subjects: Acute Disease; adult T‐cell leukaemia/lymphoma; allogeneic haematopoietic stem‐cell transplantation; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Bone marrow, stem cells transplantation. Graft versus host reaction; Chronic Disease; Feasibility Studies; Female; Follow-Up Studies; Graft vs Host Disease; Graft vs Leukemia Effect; graft‐versus‐host disease; graft‐versus‐leukaemia effect; Hematologic and hematopoietic diseases; Hematology; Hematopoietic Stem Cell Transplantation - methods; Hematopoietic Stem Cell Transplantation - mortality; Humans; Leukemia-Lymphoma, Adult T-Cell - mortality; Leukemia-Lymphoma, Adult T-Cell - surgery; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; regimen‐related toxicity; Survival Rate; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation, Homologous; Treatment Outcome; Toxicity; Stem cell; Adult T cell leukemia lymphoma; Hematopoietic cell; Homograft; Bone marrow; Graft; Complication; Evolution; Remission; Pretreatment; regimen-related toxicity; allogeneic haematopoietic stem-cell transplantation; Human; Graft versus leukemia reaction; Immunopathology; Graft versus host reaction; Malignant hemopathy; Survival; Infection; adult T-cell leukaemia/lymphoma; Treatment; graft-versus-leukaemia effect; Viral disease; graft-versus-host disease
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1046/j.1365-2141.2003.04054.x

The feasibility of allogeneic haematopoietic stem‐cell transplantation (allo‐HSCT) in 11 patients with adult T‐cell leukaemia/lymphoma (ATL) (6 acute, 4 lymphoma, 1 chronic type) was evaluated. The preparative regimens (9 conventional, 2 reduced‐intensity) were tolerable. Five patients developed acute graft‐versus‐host disease (GVHD), and three, extensive chronic GVHD. All 10 patients who survived > 30 d achieved complete remission. Estimated 1‐year overall and disease‐free survival rates were 53 ± 30% and 45 ± 29% respectively. Four patients remain alive and disease‐free at a median follow‐up of 25 months. The others died of transplantation‐related complications. This pilot study suggests that allo‐HSCT in ATL should be evaluated further.