Guidelines for performing Mendelian randomization investigations

This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ni...

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Published inWellcome open research Vol. 4; p. 186
Main Authors Burgess, Stephen, Davey Smith, George, Davies, Neil M., Dudbridge, Frank, Gill, Dipender, Glymour, M. Maria, Hartwig, Fernando P., Holmes, Michael V., Minelli, Cosetta, Relton, Caroline L., Theodoratou, Evropi
Format Journal Article
LanguageEnglish
Published London Wellcome Trust Limited 28.04.2020
F1000 Research Limited
Wellcome
Subjects
Epidemiology
Health sciences
Hypotheses
Medical research
Method
Peer review
Population
Software
Writing
United Kingdom > UK
United States > US
San Francisco California
Online AccessGet full text

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Summary:This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months.
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No competing interests were disclosed.
ISSN:2398-502X
2398-502X
DOI:10.12688/wellcomeopenres.15555.2