Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

From killers to curers: Peptides from cone snail venoms are potential therapeutic agents for the treatment of neuropathic pain. Unfortunately, these peptides suffer from the disadvantage of short biological half‐lives and poor activity when taken orally. A new orally active conotoxin was developed t...

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Published inAngewandte Chemie (International ed.) Vol. 49; no. 37; pp. 6545 - 6548
Main Authors Clark, Richard J, Jensen, Jonas, Nevin, Simon T, Callaghan, Brid P, Adams, David J, Craik, David J
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 03.09.2010
WILEY-VCH Verlag
WILEY‐VCH Verlag
Wiley
Subjects
Animals
Calcium Channel Blockers - chemical synthesis
Calcium Channel Blockers - chemistry
Calcium Channel Blockers - therapeutic use
calcium channels
Chemistry
Chemistry, Multidisciplinary
Conotoxins - chemical synthesis
Conotoxins - chemistry
Conotoxins - therapeutic use
cyclic peptides
drug design
GABAB receptor
Humans
Molecular Structure
Neuralgia - drug therapy
Neurons - cytology
Neurons - metabolism
neuropathic pain
Peptides - chemical synthesis
Peptides - chemistry
Peptides - therapeutic use
Physical Sciences
Protein Conformation
Rats
Science & Technology
cyclic peptides
neuropathic pain
GABA(B) receptor
RAT
drug design
calcium channels
NICOTINIC ACETYLCHOLINE-RECEPTORS
VC1.1
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Summary:From killers to curers: Peptides from cone snail venoms are potential therapeutic agents for the treatment of neuropathic pain. Unfortunately, these peptides suffer from the disadvantage of short biological half‐lives and poor activity when taken orally. A new orally active conotoxin was developed to solve these problems.
Bibliography:http://dx.doi.org/10.1002/anie.201000620
Work in our laboratory on cyclic conotoxins is supported by grants from the Australian Research Council (ARC) and the National Health and Medical Research Council (NHMRC). D.J.C. is a NHMRC Principal Research Fellow. R.J.C. is a NHMRC Biomedical Career Development Award Fellow. We gratefully acknowledge access to the facilities of the ARC Special Research Centre for Functional and Applied Genomics.
Australian Research Council (ARC)
National Health and Medical Research Council (NHMRC)
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ArticleID:ANIE201000620
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201000620