Nanopore-application CMOS potentiostat design with input parasitic compensation

• Published in: Electronics letters Vol. 50; no. 8; pp. 578 - 579
• Main Authors: Kim, Jungsuk, Dunbar, W.B
• Format: Journal Article
• Language: English
• Published: Stevenage The Institution of Engineering and Technology 10.04.2014; Institution of Engineering and Technology; John Wiley & Sons, Inc
• Subjects: Amplifiers; Analytical chemistry; Bandwidth; Biological and medical sciences; biological techniques; Biomedical technology; Biosensors; Biotechnology; capacitance; cascode amplifier; Chemistry; CMOS; Compensation; compensation technique; Current mirrors; Deoxyribonucleic acid; DNA; DNA translocation event detection; Electrochemical methods; Exact sciences and technology; Fundamental and applied biological sciences. Psychology; input parasitic capacitances; input resistance; low‐noise area‐efficient potentiostat design; Methods. Procedures. Technologies; molecular biophysics; nanobiotechnology; nanopore applications; nanopore sensors; nanosensors; Nanostructure; Potentiostats; Various methods and equipments; Wilson current mirror; cascode amplifier; current mirrors; capacitance; DNA translocation event detection; compensation technique; nanosensors; nanobiotechnology; nanopore sensors; low-noise area-efficient potentiostat design; input parasitic capacitances; DNA; compensation; biological techniques; nanopore applications; molecular biophysics; input resistance; Wilson current mirror; Chromosomal aberration; Spurious capacity; Cascode connection; Amplifier; Porous material; Current mirrors; Complementary MOS technology; Biosensor; Bandwidth; Potentiostat; Abnormal chromosome; Nanopore; Chromosome translocation
• ISSN: 0013-5194; 1350-911X; 1350-911X
• DOI: 10.1049/el.2014.0049

A low-noise area-efficient potentiostat design for nanopore applications is presented. By adopting a cascode amplifier and a Wilson current mirror, the input resistance is drastically decreased, which enables one to obtain a desirable bandwidth to detect DNA translocation events in nanopore sensors. A novel compensation technique is also proposed to relieve a deleterious effect by the input parasitic capacitances.