The Investigation of the Pharmacokinetics of Pulsatile-Release Salbutamol Sulfate with pH-Sensitive Ion Exchange Resin as the Carriers in Beagle Dogs

• Published in: Chemical & pharmaceutical bulletin Vol. 55; no. 3; pp. 480 - 481
• Main Authors: Liu, Hongfei, Sun, Tianhui, Yu, Feiqian, Zhao, Xin, Guo, Hong, Pan, Weisan
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.03.2007; Japan Science and Technology Agency
• Subjects: Administration, Oral; Albuterol - administration & dosage; Albuterol - blood; Albuterol - pharmacokinetics; Animals; Area Under Curve; Delayed-Action Preparations; Dogs; Drug Carriers - chemistry; Hydrogen-Ion Concentration; in vivo; ion exchange resin; Ion Exchange Resins - chemistry; pH-sensitive; pharmacokinetics; pulsatile release; salbutamol sulfate
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.55.480

We previously reported the preparation of the salbutamol sulfate pulsatile-release capsules with the pH-sensitive ion exchange resin as the carriers. In the present study, we investigated the pharmacokinetics of the salbutamol sulfate pulsatile-release capsules in beagle dogs. The analysis method was established for the drugs in vivo by HPLC method. The pharmacokinetics parameters of pulsatile-release salbutamol sulfate and reference tablet were AUC0—24 (ng·h/ml) 1031.8±123.1, 1112.6±118.24, Cmax (ng/ml) 172.4±21.4, 179.3±26.1, Tmax (h) 3.8±0.6, 1.5±0.5, Tlag (h) 2.7±0.5, 0.3±0.2. The results showed that the test dosage forms was bioequivalent with reference dosage form, and had an obviously pulsatile-release effect.