Aripiprazole, An Atypical Antipsychotic Drug, Improves Maturation and Complexity of Neuroblast Dendrites in the Mouse Dentate Gyrus Via Increasing Superoxide Dismutases

• Published in: Neurochemical research Vol. 38; no. 9; pp. 1980 - 1988
• Main Authors: Chen, Bai Hui, Yan, Bing Chun, Park, Joon Ha, Ahn, Ji Hyeon, Lee, Dae Hwan, Kim, In Hye, Cho, Jeong-Hwi, Lee, Jae-Chul, Kim, Sung Koo, Lee, Bonghee, Cho, Jun Hwi, Won, Moo-Ho, Lee, Yun Lyul
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.09.2013; Springer Nature B.V
• Subjects: Adolescence; Animals; Antipsychotic Agents - pharmacology; Aripiprazole; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell Differentiation - drug effects; Cell Proliferation - drug effects; Dentate Gyrus - cytology; Dentate Gyrus - drug effects; Dentate Gyrus - enzymology; Male; Mice; Mice, Inbred ICR; Neurochemistry; Neurology; Neurons - drug effects; Neurosciences; Original Paper; Piperazines - pharmacology; Quinolones - pharmacology; Superoxide Dismutase - metabolism; Cell proliferation; Antioxidants; Atypical antipsychotic; Neurogenesis; Neuroblast differentiation
• ISSN: 0364-3190; 1573-6903
• DOI: 10.1007/s11064-013-1104-2

Apripiprazole (APZ) is well known as an atypical antipsychotic and antidepressant. In the present study, we investigated effects of APZ on cell proliferation and neuronal differentiation in the dentate gyrus (DG) of the adolescent mouse using BruU, Ki-67 and doublecortin (DCX) immunohistochemistry. BruU, Ki-67 and DCX-positive (+) cells were easily detected in the subgranular zone of the DG in the vehicle- and APZ-treated group. We found that in the 8 mg/kg APZ-treated group numbers of Ki-67 + , DCX + and BrdU + /DCX + cells were significantly increased compared with those in the vehicle-treated group. We also found that maturation and complexity of DCX + dendrites in the 8 mg/kg APZ-treated group was well improved compared with those in the vehicle-treated group. In addition, markedly decreased lipid peroxidation and increased superoxide dismutase 2 (SOD2) level were observed in the DG of the 8 mg/kg APZ-treated group. Our present findings indicate that APZ can enhance cell proliferation and neuroblast differentiation, particularly maturation and complexity of neuroblast dendrites, in the DG via decreasing lipid peroxidation and increasing SOD2 level.