The Protective Effect of Curcumin on Ionizing Radiation-induced Cataractogenesis in Rats

• Published in: Balkan medical journal Vol. 29; no. 4; pp. 358 - 363
• Main Authors: Ozgen, Seher Çimen, Dökmeci, Dikmen, Akpolat, Meryem, Karadağ, Cetin Hakan, Gündüz, Ozgür, Erbaş, Hakan, Benian, Omer, Uzal, Cem, Turan, Fatma Nesrin
• Format: Journal Article
• Language: English
• Published: Turkey AVES 01.12.2012; Galenos Publishing House
• Subjects: Cataract; curcumin; ionizing radiation; lipid peroxidation; Original; oxidative stress; radioprotective; Cataract; radioprotective; lipid peroxidation; ionizing radiation; oxidative stress; curcumin
• ISSN: 2146-3123; 2146-3131
• DOI: 10.5152/balkanmedj.2012.038

The aim of the study was to determine the protective effect of curcumin against ionizing radiation-induced cataract in the lens of rats. Rats were divided into six groups. Group 1: Control, Group 2: Dimethyl sulfoxide (DMSO), Group 3: DMSO+curcumin, Group 4: Irradiation, Group 5: Irradiation+DMSO, Group 6: Irradiation+DMSO+curcumin. A 15 Gy total dose was given to 4, 5, 6 groups for radiation damage. Curcumin (100 mg/kg) was dissolved in DMSO and given by intragastric intubation for 28 days. At the end of the experiment, lenses were graded and enucleated. The lenticular activity of the antioxidant enzymes, total antioxidant and glutathione peroxidase (GSH-Px), and the malondialdehyde (MDA) were measured. 100% Cataract was seen in the irradiation group. Cataract rate fell to 40% and was limited at grade 1 and 2 in the curcumin group. In the irradiation group, antioxidant enzyme levels were decreased, MDA levels were increased. There was an increase in antioxidant enzyme levels and a significant decrease in MDA in the group which was given curcumin. Curcumin has antioxidant and radioprotective properties and is likely to be a valuable agent for protection against ionizing radiation. Hence, it may be used as an antioxidant and radioprotector against radiation-induced cataractogenesis.