The epidemiology of gastroenteropancreatic neuroendocrine tumors

• Published in: Endocrinology and metabolism clinics of North America Vol. 40; no. 1; p. 1
• Main Authors: Lawrence, Ben, Gustafsson, Bjorn I, Chan, Anthony, Svejda, Bernhard, Kidd, Mark, Modlin, Irvin M
• Format: Journal Article
• Language: English
• Published: United States 01.03.2011
• Subjects: Gastrointestinal Neoplasms - epidemiology; Gastrointestinal Neoplasms - mortality; Humans; Incidence; Neuroendocrine Tumors - epidemiology; Neuroendocrine Tumors - mortality; Pancreatic Neoplasms - epidemiology; Pancreatic Neoplasms - mortality; SEER Program; Time Factors; United States - epidemiology; United States
• ISSN: 1558-4410
• DOI: 10.1016/j.ecl.2010.12.005

In this article, updated analyses of the National Cancer Institute Surveillance, Epidemiology and End Results (SEER) registry (1973-2007) are presented and compared with epidemiologic GEP-NET data from Europe and Asia. Several studies have demonstrated a steadily increasing incidence of GEP-NETs, and this escalation is still ongoing (SEER data 2004-2007). The common primary GEP-NET sites exhibit unique epidemiologic profiles with distinct patterns of incidence, age at diagnosis, stage, and survival. Overall, GEP-NET survival has improved over the past 3 decades, although the outcome for poorly differentiated tumors remains dismal.