Escalation in high fat intake in a binge eating model differentially engages dopamine neurons of the ventral tegmental area and requires ghrelin signaling

• Published in: Psychoneuroendocrinology Vol. 60; pp. 206 - 216
• Main Authors: Valdivia, Spring, Cornejo, María P, Reynaldo, Mirta, De Francesco, Pablo N, Perello, Mario
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2015
• Subjects: Animals; Anticipation, Psychological - drug effects; Appetite; Bulimia - physiopathology; Diet, High-Fat - adverse effects; Dopaminergic Neurons - drug effects; Endocrinology & Metabolism; Female; Food reward; Ghrelin; Ghrelin - physiology; Male; Mesolimbic pathway; Mice; Mice, Inbred C57BL; Motor Activity - drug effects; Nucleus accumbens; Nucleus Accumbens - cytology; Nucleus Accumbens - metabolism; Orexin; Orexins - physiology; Proto-Oncogene Proteins c-fos - metabolism; Psychiatry; Signal Transduction - drug effects; Ventral Tegmental Area - cytology; Ventral Tegmental Area - drug effects; Ventral Tegmental Area - metabolism; Appetite; Nucleus accumbens; Food reward; Ghrelin; Orexin; Mesolimbic pathway
• ISSN: 0306-4530; 1873-3360
• DOI: 10.1016/j.psyneuen.2015.06.018

Highlights • Four daily accesses to HFD for 2 h induce hyperphagia with an escalating profile. • Four daily accesses to HFD for 2 h induce differential activation of neurons of the mesolimbic pathway. • Four daily accesses to HFD for 2 h induce activation of the hypothalamic orexin neurons. • Orexin signaling blockage fails to affect escalation of HFD intake. • Ghrelin receptor deficient mice fail to escalate the HFD consumption over the successive days of exposure.