Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging

Magnetic resonance imaging examinations are frequently carried out using contrast agents to improve the image quality. Practically all clinically used contrast agents are based on paramagnetic metals and lack in selectivity and specificity. A group of stable organic radicals, nitroxides, has raised...

Full description

Saved in:
Bibliographic Details
Published inContrast media and molecular imaging Vol. 2019; no. 2019; pp. 1 - 8
Main Authors Heikkinen, Sami, Kavakka, Jari, Laakkonen, Johanna P., Rönkkö, Seppo, Olsson, Venla, Nivajärvi, Riikka, Kettunen, Mikko I., Soikkeli, Maiju, Lehto, Vesa-Pekka
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2019
Hindawi
Hindawi Limited
Subjects
Animals
Cell culture
Contrast agents
Contrast Media - pharmacology
Cyclic N-Oxides - chemistry
Cyclic N-Oxides - pharmacology
Cytotoxicity
Electron Spin Resonance Spectroscopy
Experiments
Glucose
HeLa Cells
Humans
Image contrast
Image quality
Magnetic properties
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medical imaging
Metals
Neoplasms - diagnostic imaging
Neoplasms - pathology
Neuroimaging
Nitroxide
NMR
Nuclear magnetic resonance
Penicillin
Piperidines - chemistry
Piperidines - pharmacology
Rats
Relaxation time
Resonance
Selectivity
Spin Labels
Tumors
United Kingdom > UK
United States > US
Finland
Online AccessGet full text

Cover

More Information
Summary:Magnetic resonance imaging examinations are frequently carried out using contrast agents to improve the image quality. Practically all clinically used contrast agents are based on paramagnetic metals and lack in selectivity and specificity. A group of stable organic radicals, nitroxides, has raised interest as new metal-free contrast agents for MRI. Their structures can easily be modified to incorporate different functionalities. In the present study, a stable nitroxide TEEPO (2,2,6,6-tetraethylpiperidin-1-oxyl) was linked to a glucose moiety (Glc) to construct a water-soluble, potentially tumor-targeting compound with contrast-enhancing ability. The ability was assessed with in vivo MRI experiments. The constructed TEEPO-Glc agent proved to shorten the T1 relaxation time in tumor, while the T1 time in healthy brain tissue remained the same. The results indicate the potential of TEEPO-Glc as a valuable addition to the growing field of metal-free contrast enhancement in MRI-based diagnostics.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Guillermina Ferro-Flores
ISSN:1555-4309
1555-4317
DOI:10.1155/2019/5629597