Oncogene expression in cervical intraepithelial neoplasia and invasive cancer of cervix
Expression of the oncogenes Ha-RAS, c-MYC, and ERB-2 was investigated with an automated image analysis system in 12 specimens of normal cervix, 10 of cervical intraepithelial neoplasia (CIN) grade 1,24 of CIN 3, and 10 of invasive cancer of the cervix. There was amplification of all three onocogenes...
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Published in | The Lancet (British edition) Vol. 337; no. 8745; pp. 819 - 820 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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London
Elsevier Ltd
06.04.1991
Lancet Elsevier Limited |
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Abstract | Expression of the oncogenes Ha-RAS, c-MYC, and ERB-2 was investigated with an automated image analysis system in 12 specimens of normal cervix, 10 of cervical intraepithelial neoplasia (CIN) grade 1,24 of CIN 3, and 10 of invasive cancer of the cervix. There was amplification of all three onocogenes in CIN 3 and invasive cancer compared with normal cervix and CIN 1. The difference was most pronounced with an antibody to the RAS p21 protein, with no overlap between CIN 3 and the normal range. This method might be useful in screening for cervical neoplasia, and for the determination of which CIN lesions require treatment. |
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AbstractList | Expression of the oncogenes Ha-RAS, c-MYC, and ERB-2 was investigated with an automated image analysis system in 12 specimens of normal cervix, 10 of cervical intraepithelial neoplasia (CIN) grade 1, 24 of CIN 3, and 10 of invasive cancer of the cervix. There was amplification of all three oncogenes in CIN 3 and invasive cancer compared with normal cervix and CIN 1. The difference was most pronounced with an antibody to the RAS p21 protein, with no overlap between CIN 3 and the normal range. This method might be useful in screening for cervical neoplasia, and for the determination of which CIN lesions require treatment. Expression of the oncogenes Ha-RAS, c-MYC, and ERB-2 was investigated with an automated image analysis system in 12 specimens of normal cervix, 10 of cervical intraepithelial neoplasia (CIN) grade 1,24 of CIN 3, and 10 of invasive cancer of the cervix. There was amplification of all three onocogenes in CIN 3 and invasive cancer compared with normal cervix and CIN 1. The difference was most pronounced with an antibody to the RAS p21 protein, with no overlap between CIN 3 and the normal range. This method might be useful in screening for cervical neoplasia, and for the determination of which CIN lesions require treatment. |
Author | Kennedy, J.H. Pinion, S.B. Miller, R.W. MacLean, A.B. |
Author_xml | – sequence: 1 givenname: S.B. surname: Pinion fullname: Pinion, S.B. organization: Department of Gynaecology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB9 2ZB, UK – sequence: 2 givenname: J.H. surname: Kennedy fullname: Kennedy, J.H. organization: Department of Gynaecology, Glasgow Royal Infirmary, Glasgow, United Kingdom – sequence: 3 givenname: R.W. surname: Miller fullname: Miller, R.W. organization: Department of Biomedical Instrumentation, University of Strathclyde, Glasgow, United Kingdom – sequence: 4 givenname: A.B. surname: MacLean fullname: MacLean, A.B. organization: Department of Gynaecology, Western Infirmary, Glasgow, United Kingdom |
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Keywords | Cervical dysplasia C-Onc gene Tumor Uterine cervix Malignant tumor Gene expression Female genital diseases |
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and cmyc oncogene in human genital tumours publication-title: Int J Cancer doi: 10.1002/ijc.2910430407 contributor: fullname: Di Luca |
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SubjectTerms | Biological and medical sciences c-Myc protein Cancer Carcinoma in Situ - genetics Cervical cancer Evaluation Studies as Topic Female Female genital diseases GTP-binding protein Gynecology. Andrology. Obstetrics Health risk assessment Histological Techniques Human papillomavirus Humans Image analysis Image processing Invasiveness Lesions Medical research Medical sciences Myc protein Oncogene Protein p21(ras) - analysis Oncogene Protein p55(v-myc) - analysis Oncogene Proteins v-erbA Oncogenes Proteins Reproductive system Retroviridae Proteins, Oncogenic - analysis Tumors Uterine Cervical Neoplasms - genetics |
Title | Oncogene expression in cervical intraepithelial neoplasia and invasive cancer of cervix |
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