Oncogene expression in cervical intraepithelial neoplasia and invasive cancer of cervix
Expression of the oncogenes Ha-RAS, c-MYC, and ERB-2 was investigated with an automated image analysis system in 12 specimens of normal cervix, 10 of cervical intraepithelial neoplasia (CIN) grade 1,24 of CIN 3, and 10 of invasive cancer of the cervix. There was amplification of all three onocogenes...
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Published in | The Lancet (British edition) Vol. 337; no. 8745; pp. 819 - 820 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
London
Elsevier Ltd
06.04.1991
Lancet Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Expression of the oncogenes Ha-RAS, c-MYC, and ERB-2 was investigated with an automated image analysis system in 12 specimens of normal cervix, 10 of cervical intraepithelial neoplasia (CIN) grade 1,24 of CIN 3, and 10 of invasive cancer of the cervix. There was amplification of all three onocogenes in CIN 3 and invasive cancer compared with normal cervix and CIN 1. The difference was most pronounced with an antibody to the RAS p21 protein, with no overlap between CIN 3 and the normal range. This method might be useful in screening for cervical neoplasia, and for the determination of which CIN lesions require treatment. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0140-6736 1474-547X |
DOI: | 10.1016/0140-6736(91)92518-7 |