Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7

By using the 10BASE(d)-T, we have synthesized a crown ether-like macrocyclic library possessing randomized peptide linkers on bacteriophage T7. Among 1.5 x 10(9) diversities of the supramolecule candidates, we have obtained a specific binder for the N-terminal domain of Hsp90.

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 50; no. 30; pp. 3921 - 3923
Main Authors Fukunaga, Keisuke, Hatanaka, Takaaki, Ito, Yuji, Minami, Michiko, Taki, Masumi
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2014
Subjects
Bacteria
Bacteriophage T7 - genetics
Chemistry
Chemistry, Multidisciplinary
Crown Ethers - chemical synthesis
Crown Ethers - chemistry
Macromolecular Substances - chemical synthesis
Macromolecular Substances - chemistry
Molecular Structure
Peptides - chemistry
Peptides - genetics
Physical Sciences
Science & Technology
HSP90
CANCER
COMPLEX
Online AccessGet full text

Cover

More Information
Summary:By using the 10BASE(d)-T, we have synthesized a crown ether-like macrocyclic library possessing randomized peptide linkers on bacteriophage T7. Among 1.5 x 10(9) diversities of the supramolecule candidates, we have obtained a specific binder for the N-terminal domain of Hsp90.
Bibliography:KAKEN
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc00811a