A NOVEL HOMOISOCARBACYCLIN ANALOG WITH POTENT AND LONG-LASTING ACTIVITY

A synthesis of a novel and chemically stable homoisocarbacyclin analog, TY-11223 (3___-), has been accomplished.The analog (3___-), given intravenously or orally, showed potent and long-lasting activities in inhibiting platelet aggregation and, in addition, a good selectivity in biological activitie...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 40; no. 1; pp. 279 - 281
Main Authors SHIBASAKI, Masakatsu, TAKAHASHI, Atsuo, AOKI, Tsuyoshi, SATO, Hiroyasu, YAMADA, Shin-ichi, KUDO, Michiko, KOGI, Kentaro, NARITA, Sen-ichi
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.01.1992
Maruzen
Subjects
Alicyclic compounds, terpenoids, prostaglandins, steroids
Animals
Chemistry
Epoprostenol - analogs & derivatives
Epoprostenol - chemical synthesis
Epoprostenol - pharmacology
Exact sciences and technology
homoisocarbacyclin analog
hypotensive effect
iloprost
In Vitro Techniques
isocarbacyclin analog
Organic chemistry
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors - chemical synthesis
Platelet Aggregation Inhibitors - pharmacology
platelet antiaggregation activity
Preparations and properties
prostacyclin
Prostaglandins
Rabbits
TY-11223
Ether
Prostaglandin
Carboxylic acid
Aliphatic compound
Bicyclic compound
Secondary alcohol
Dienic compound
Biological activity
Homoallylic compound
Antiplatelet agent
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Summary:A synthesis of a novel and chemically stable homoisocarbacyclin analog, TY-11223 (3___-), has been accomplished.The analog (3___-), given intravenously or orally, showed potent and long-lasting activities in inhibiting platelet aggregation and, in addition, a good selectivity in biological activities.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.40.279