The Effect of Maximum Voided Volume on Response to Desmopressin Therapy in Children with Enuresis

• Published in: Journal of Nippon Medical School Vol. 79; no. 4; pp. 255 - 258
• Main Authors: Okur, Mesut, Ozen, Semiha Fatma, Kocabay, Kenan, Cam, Kamil, Ozkan, Aybars, Uzun, Hakan
• Format: Journal Article
• Language: English
• Published: Japan The Medical Association of Nippon Medical School 2012
• Subjects: Adolescent; Child; children; Deamino Arginine Vasopressin - pharmacology; Deamino Arginine Vasopressin - therapeutic use; desmopressin; Enuresis - drug therapy; Enuresis - physiopathology; enuresis nocturna; Female; Humans; Male; maximum voided volume; Treatment Outcome; Urinary Bladder - drug effects; Urinary Bladder - physiopathology; Urination - drug effects
• ISSN: 1345-4676; 1347-3409
• DOI: 10.1272/jnms.79.255

Purpose: This study was aimed to determine the effect of maximum voided volume (MVV) on the efficacy of desmopressin, which is commonly used to treat primary monosymptomatic nocturnal enuresis (PMNE) in children and adolescents. Materials and Methods: Bladder capacity was measured with different methods in 52 patients with PMNE, and the effect of bladder capacity on desmopressin therapy was investigated. Results: Patients with PMNE in whom MVV was 70% or less of estimated bladder capacity were found to be unresponsive to desmopressin therapy. Conclusion: The MVV can be measured before desmopressin therapy in patients with PMNE as a marker to predict treatment success. Our results suggest that desmopressin should not be used in patients with low MVV.