Corticosterone regulates fear memory via Rac1 activity in the hippocampus
Highlights • Stress generates fear-specific memories and G-protein Rac1 may play a role in this. • Stress and exogenous corticosterone downregulated activity Rac1. • RU38486, glucocorticoid receptor agonist, recovered activity Rac1 and decreased memory. • The glucocorticoid receptor inhibitor NSC237...
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Published in | Psychoneuroendocrinology Vol. 71; pp. 86 - 93 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.09.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • Stress generates fear-specific memories and G-protein Rac1 may play a role in this. • Stress and exogenous corticosterone downregulated activity Rac1. • RU38486, glucocorticoid receptor agonist, recovered activity Rac1 and decreased memory. • The glucocorticoid receptor inhibitor NSC23766 increased fear memory retrieval. • Rac1 may thus be therapeutic targets in stress and memory disorders. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0306-4530 1873-3360 |
DOI: | 10.1016/j.psyneuen.2016.05.011 |