Research Advances in the Mechanisms of Hyperuricemia-Induced Renal Injury

Uric acid is the end product of purine metabolism in humans, and its excessive accumulation leads to hyperuricemia and urate crystal deposition in tissues including joints and kidneys. Hyperuricemia is considered an independent risk factor for cardiovascular and renal diseases. Although the symptoms...

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Published inBioMed research international Vol. 2020; no. 2020; pp. 1 - 12
Main Authors Liu, Hua-feng, Liang, Dong, Yang, Chen, Su, Hong-yong
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2020
Hindawi
Hindawi Limited
Subjects
Antioxidants
Apoptosis
Biomedical research
Cardiovascular diseases
Diabetes
Enzymes
Fibrosis
Health risks
Humans
Hyperuricemia
Hyperuricemia - blood
Hyperuricemia - complications
Hyperuricemia - pathology
Inflammation - blood
Inflammation - pathology
Injuries
Joint diseases
Kidney - injuries
Kidney - metabolism
Kidney - pathology
Kidney diseases
Kidney Diseases - blood
Kidney Diseases - etiology
Kidney Diseases - pathology
Metabolism
Metabolites
Mitochondria
Molecular modelling
Oxidative Stress
Proteins
Renal function
Review
Risk analysis
Risk factors
Senescence
Signs and symptoms
Studies
Uric acid
China
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Summary:Uric acid is the end product of purine metabolism in humans, and its excessive accumulation leads to hyperuricemia and urate crystal deposition in tissues including joints and kidneys. Hyperuricemia is considered an independent risk factor for cardiovascular and renal diseases. Although the symptoms of hyperuricemia-induced renal injury have long been known, the pathophysiological molecular mechanisms are not completely understood. In this review, we focus on the research advances in the mechanisms of hyperuricemia-caused renal injury, primarily on oxidative stress, endothelial dysfunction, renal fibrosis, and inflammation. Furthermore, we discuss the progress in hyperuricemia management.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Academic Editor: Maria Stangou
ISSN:2314-6133
2314-6141
DOI:10.1155/2020/5817348