Role of cell cycle regulators in adipose tissue and whole body energy homeostasis

• Published in: Cellular and molecular life sciences : CMLS Vol. 75; no. 6; pp. 975 - 987
• Main Authors: Lopez-Mejia, I. C., Castillo-Armengol, J., Lagarrigue, S., Fajas, L.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2018; Springer Nature B.V
• Subjects: Adipocytes; Adipose tissue; Adipose Tissue - metabolism; Animals; Biochemistry; Biomedical and Life Sciences; Biomedicine; Browning; Cell Biology; Cell cycle; Cell Cycle Checkpoints; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell division; Cyclin-Dependent Kinase Inhibitor Proteins - genetics; Cyclin-Dependent Kinase Inhibitor Proteins - metabolism; Cyclin-Dependent Kinases - genetics; Cyclin-Dependent Kinases - metabolism; Cyclins - genetics; Cyclins - metabolism; Differentiation; E2F Transcription Factors - genetics; E2F Transcription Factors - metabolism; Energy balance; Energy Metabolism; Homeostasis; Humans; Life Sciences; Lipogenesis; Lipolysis; Machinery and equipment; Metabolism; Mitochondria; Regulators; Review; Tissues; Obesity; Adipose tissue; CDKs; Cell cycle; Insulin resistance; Metabolism; Cyclins
• ISSN: 1420-682X; 1420-9071
• DOI: 10.1007/s00018-017-2668-9

In the course of the last decades, metabolism research has demonstrated that adipose tissue is not an inactive tissue. Rather, adipocytes are key actors of whole body energy homeostasis. Numerous novel regulators of adipose tissue differentiation and function have been identified. With the constant increase of obesity and associated disorders, the interest in adipose tissue function alterations in the XXIst century has become of paramount importance. Recent data suggest that adipocyte differentiation, adipose tissue browning and mitochondrial function, lipogenesis and lipolysis are strongly modulated by the cell division machinery. This review will focus on the function of cell cycle regulators in adipocyte differentiation, adipose tissue function and whole body energy homeostasis; with particular attention in mouse studies.