Expression of Progranulin (Acrogranin/PCDGF/Granulin-Epithelin Precursor) in Benign and Malignant Ovarian Tumors and Activation of MAPK Signaling in Ovarian Cancer Cell Line

ABSTRACT It has been recently demonstrated that progranulin is overexpressed in ovarian cancer and that this protein is involved in the stimulation of cell proliferation, malignancy, and chemoresistance in ovarian cancer. The goal of the present study was to establish the differences in progranulin...

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Published inCancer investigation Vol. 28; no. 5; pp. 452 - 458
Main Authors Cuevas-Antonio, R., Cancino, C., Arechavaleta-Velasco, F., Andrade, A., Barron, L., Estrada, I., Fernandez, R. L., Olguin, V., Ruiz, S., Imani, F., Zeferino-Toquero, M., Ulloa-Aguirre, A., Gerton, G. L., Diaz-Cueto, L.
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.05.2010
Taylor & Francis
Subjects
Adult
Aged
Aged, 80 and over
Apoptosis
Cell Line
Cell Line, Tumor
Cell Proliferation
Cell Survival
Female
Granulin/epithelin precursor
Humans
Intercellular Signaling Peptides and Proteins - genetics
Intercellular Signaling Peptides and Proteins - metabolism
MAP Kinase Signaling System
Middle Aged
Ovarian cancer
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - mortality
Ovary - metabolism
Progranulin
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Summary:ABSTRACT It has been recently demonstrated that progranulin is overexpressed in ovarian cancer and that this protein is involved in the stimulation of cell proliferation, malignancy, and chemoresistance in ovarian cancer. The goal of the present study was to establish the differences in progranulin expression among normal, benign, and malignant ovarian tissues and to identify the signal transduction pathways activated by progranulin in an ovarian cancer cell line. Compared with benign tumors and normal ovarian tissue, progranulin mRNA and protein were overexpressed in malignant tumors. Survival analysis by the Kaplan-Meier method showed a correlation between high mRNA expression levels with poor survival outcome. Progranulin activated the MAPK-signaling pathway in NIH-OVCAR-3 cells. Progranulin expression may be potentially involved in the pathogenesis and malignant progression of ovarian cancer, and thus may represent a therapeutic target for this particular malignancy.
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ISSN:0735-7907
1532-4192
DOI:10.3109/07357900903346455