Copper-Catalyzed Intramolecular Olefinic C(sp2)–H Amidation for the Synthesis of γ-Alkylidene-γ-lactams

Herein, we report the copper-catalyzed dehydrogenative C(sp2)–N bond formation of 4-pentenamides via nitrogen-centered radicals. This reaction provides a straightforward and efficient preparation method for γ-alkylidene-γ-lactams. Notably, we could controllably synthesize α,β-unsaturated- or α,β-sat...

Full description

Saved in:
Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 28; no. 18; p. 6682
Main Authors Nozawa-Kumada, Kanako, Hayashi, Masahito, Kwon, Eunsang, Shigeno, Masanori, Yada, Akira, Kondo, Yoshinori
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 18.09.2023
MDPI
Subjects
C(sp2)–H amidation
Communication
copper-catalyst
cross-dehydrogenative coupling
Hydrocarbons
Investigations
Nitrogen
nitrogen-centered radical
Oxidation
γ-alkylidene-γ-lactam
Online AccessGet full text

Cover

More Information
Summary:Herein, we report the copper-catalyzed dehydrogenative C(sp2)–N bond formation of 4-pentenamides via nitrogen-centered radicals. This reaction provides a straightforward and efficient preparation method for γ-alkylidene-γ-lactams. Notably, we could controllably synthesize α,β-unsaturated- or α,β-saturated-γ-alkylidene-γ-lactams depending on the reaction conditions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28186682