Simulation model based on non-newtonian fluid mechanics applied to the evaluation of the embolic effect of emulsions of iodized oil and anticancer drug

• Published in: Cardiovascular and interventional radiology Vol. 23; no. 4; pp. 285 - 290
• Main Authors: DEMACHI, Hiroshi, MATSUI, Osamu, ABO, Hitoshi, TATSU, Hiroki
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.07.2000; Berlin Springer Nature B.V
• Subjects: Antibiotics, Antineoplastic - pharmacology; ANTINEOPLASTIC DRUGS; Biological and medical sciences; Carcinoma, Hepatocellular - therapy; Chemoembolization, Therapeutic - methods; Contrast Media - pharmacology; Drug Combinations; Emulsions; Epirubicin - pharmacology; EVALUATION; FLUID MECHANICS; Hepatic Artery; Humans; Injections, Intra-Arterial; Investigative techniques, diagnostic techniques (general aspects); Iodized Oil - pharmacology; Iopamidol - pharmacology; Liver Neoplasms - therapy; Medical sciences; Miscellaneous. Technology; Models, Biological; NEOPLASMS; Radiodiagnosis. Nmr imagery. Nmr spectrometry; RADIOLOGY AND NUCLEAR MEDICINE; SIMULATION; STEADY FLOW; VASCULAR DISEASES; Viscosity; Antineoplastic agent; Non Newtonian fluid; Human; Chemotherapy; Water oil emulsion; Oil water emulsion; Technology; Interventional radiology; Anthracyclins; Epirubicin; Simulation model; Technique
• ISSN: 0174-1551; 1432-086X
• DOI: 10.1007/s002700010070

To verify the difference in embolic effect between oil-in-water (O-W) and water-in-oil (W-O) emulsions composed of iodized oil and an anticancer drug, epirubicin, using a simulation model based on non-Newtonian fluid mechanics. Flow curves of pure iodized oil and two types of O-W and W-O emulsions immediately and 1 hr after preparation were examined with a viscometer. Using the yield stress data obtained, we simulated the stagnation of each fluid with steady flow in a rigid tube. The W-O emulsions were observed to stagnate in the thin tube at a low pressure gradient. However, the embolic effect of the W-O emulsions decreased 1 hr after preparation. The O-W emulsions were stable and did not stagnate under the conditions in which the W-O emulsions stagnated. The simulation model showed that the embolic effect of the W-O emulsions was superior to that of the O-W emulsions.