In vitro antibiotic susceptibilities of Burkholderia mallei (causative agent of glanders) determined by broth microdilution and E-test

• Published in: Antimicrobial agents and chemotherapy Vol. 45; no. 7; pp. 2119 - 2121
• Main Authors: HEINE, Henry S, ENGLAND, Marilyn J, WAAG, David M, BYRNE, W. Russell
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.07.2001
• Series: Note
• Subjects: Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Burkholderia - drug effects; Burkholderia - isolation & purification; Burkholderia Infections - microbiology; Burkholderia mallei; Culture Media - pharmacology; Glanders - microbiology; Humans; Medical sciences; Microbial Sensitivity Tests - methods; Pharmacology. Drug treatments; Susceptibility; Tetracycline derivatives; β-Lactams; Macrolide; Biological activity; Penicillin derivatives; Carbapenem derivatives; Cephalosporin derivatives; Fluoroquinolone derivatives; Sensitivity resistance; Aminoglycoside; Piperacillin; Doxycycline; Bacteria; Burkholderia mallei; Antibacterial agent; Quinolone derivatives; Ceftazidime; Imipenem
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.45.7.2119-2121.2001

In vitro susceptibilities to 28 antibiotics were determined for 11 strains of Burkholderia mallei by the broth microdilution method. The B. mallei strains demonstrated susceptibility to aminoglycosides, macrolides, quinolones, doxycycline, piperacillin, ceftazidime, and imipenem. For comparison and evaluation, 17 antibiotic susceptibilities were also determined by the E-test. E-test values were always lower than the broth dilution values. Establishing and comparing antibiotic susceptibilities of specific B. mallei strains will provide reference information for assessing new antibiotic agents.