Concentrations of polychlorinated dibenzo- p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in blood and breast milk collected from pregnant women in Sapporo City, Japan

• Published in: Chemosphere (Oxford) Vol. 85; no. 11; pp. 1694 - 1700
• Main Authors: Todaka, Takashi, Hirakawa, Hironori, Kajiwara, Jumboku, Onozuka, Daisuke, Sasaki, Seiko, Miyashita, Chihiro, Yoshioka, Eiji, Yuasa, Motoyuki, Kishi, Reiko, Iida, Takao, Uchi, Hiroshi, Furue, Masutaka
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.12.2011; Elsevier
• Subjects: Adult; analogs & derivatives; Applied sciences; Benzofurans; Benzofurans - blood; Biological and medical sciences; biphenyl; blood; blood sampling; breast milk; chemistry; chlorine; cities; Cohort Studies; Dibenzofurans, Polychlorinated; Environment. Living conditions; Exact sciences and technology; Female; Human blood; Human breast milk; Humans; Japan; lipids; Medical sciences; Milk, Human; Milk, Human - chemistry; mothers; Pollution; Polychlorinated biphenyls; Polychlorinated Biphenyls - blood; Polychlorinated dibenzo- p-dioxins; polychlorinated dibenzodioxins; Polychlorinated Dibenzodioxins - analogs & derivatives; Polychlorinated Dibenzodioxins - blood; Polychlorinated dibenzofurans; Pregnancy; pregnant women; Public health. Hygiene; Public health. Hygiene-occupational medicine; Sapporo City; toxicity; Asia; Japan; Japan, Hokkaido, Sapporo; Polychlorinated dibenzo- p-dioxins; Polychlorinated biphenyls; Human breast milk; Sapporo City; Polychlorinated dibenzofurans; Human blood; Human; Polychlorinated dibenzo-p-dioxins; Dioxin derivatives; Urban environment; Polychlorobiphenyls; Urban area; Epidemiology; Blood; Persistent organic pollutant; Pregnancy; Halogenated hydrocarbon; Health and environment; Chlorocarbon; Human milk; Poison; Aromatic compound; Woman; Organic compounds; Breast milk
• ISSN: 0045-6535; 1879-1298; 1879-1298
• DOI: 10.1016/j.chemosphere.2011.09.014

► In this study we will provide new information. ► We examine the partition ratios of dioxins from blood to breast milk in women. ► We also investigate the effect of delivery on the partition ratios. ► We find the characteristic congeners of PCBs regarding the partition. ► These results will aid in future epidemiological investigations in child. We measured the concentrations of polychlorinated dibenzo- p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), dioxin-like polychlorinated biphenyls (PCBs), and non-dioxin-like PCBs in paired samples of blood and breast milk collected from 67 secundiparas in Sapporo City, Japan, and combined this data with those of the 30 secundiparas previously measured. The arithmetic mean total toxic equivalents (TEQ-WHO) concentrations of PCDDs, PCDFs, non- ortho PCBs, and mono- ortho PCBs in blood and breast milk of the 97 secundiparous subjects were 3.0–23 (mean: 13, median: 14) and 2.7–20 (mean: 8.6, median: 8.5) pg TEQ g −1 lipid, respectively. The sums of the concentrations of 56 non-dioxin-like PCB congeners that were measured in the subjects’ blood and breast milk were 16–326 (mean: 107, median: 100) and 12–252 (mean: 73, median: 67) ng g −1 lipid, respectively. The partitioning ratios of individual congeners of PCDDs, PCDFs, dioxin-like PCBs, and non-dioxin-like PCBs from blood to breast milk in secundiparas were almost the same as those of primiparas that have been recently reported, suggesting that the partitioning ratios of these compounds from maternal blood to breast milk in women is little affected by delivery. Furthermore, the partition of PCB congeners with chlorine at the 2-, 3-, 4′-, and 5-positions or the 2-, 4-, 4′-, and 5-positions of the biphenyl ring from the blood to the breast milk tended to occur at a higher level than that of other congeners. In particular, the levels of tetraCB-74 and hexaCB-146 in the breast milk for both primiparous and secundiparous mothers were slightly higher than those in the blood.