Anti-diarrhoeal activity of Butea monosperma in experimental animals

• Published in: Journal of ethnopharmacology Vol. 98; no. 3; pp. 241 - 244
• Main Authors: Gunakkunru, A., Padmanaban, K., Thirumal, P., Pritila, J., Parimala, G., Vengatesan, N., Gnanasekar, N., Perianayagam, James B., Sharma, S.K., Pillai, K.K.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 26.04.2005; Elsevier
• Subjects: Animals; Anti-diarrhoeal; antidiarrheal effect; Antidiarrheals - pharmacology; Antidiarrheals - therapeutic use; Antidiarrheals - toxicity; bark; Biological and medical sciences; Butea; Butea monosperma; Diarrhea - chemically induced; Diarrhea - drug therapy; Fabaceae; Gastrointestinal motility; Gastrointestinal Motility - drug effects; General pharmacology; Intestinal secretion; Male; Medical sciences; medicinal plants; Mice; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; phytochemicals; Phytotherapy; Plant Bark; plant extracts; Plant Preparations - pharmacology; Plant Preparations - therapeutic use; Plant Preparations - toxicity; Rats; Rats, Wistar; stems; traditional medicine; Intestinal secretion; Anti-diarrhoeal; Gastrointestinal motility; Butea monosperma; Fabaceae; Stomach; Motility; Digestive system; Pharmacognosy; Secretion; Gut; Gastrointestinal; Medicinal plant; Leguminosae; Dicotyledones; Animal; Angiospermae; Plant origin; Spermatophyta
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2004.12.021

The anti-diarrhoeal potential of the ethanolic extract of stem bark of Butea monosperma (Lam) Kuntz has been evaluated using several experimental models in Wistar albino rats. The extract inhibited castor oil induced diarrhoea and PGE 2 induced enteropooling in rats; it also reduced gastrointestinal motility after charcoal meal administration. The results obtained establish the efficacy and substantiate the use of this herbal remedy as a non-specific treatment for diarrhoea in folk medicine.