Psychopathic individuals exhibit but do not avoid regret during counterfactual decision making

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 50; pp. 14438 - 14443
• Main Authors: Baskin-Sommers, Arielle, Stuppy-Sullivan, Allison M., Buckholtz, Joshua W.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 13.12.2016
• Subjects: Adolescent; Adult; Affect; Antisocial personality disorder; Antisocial Personality Disorder - psychology; Biological Sciences; Choice Behavior; Cognitive models; Criminal Behavior; Decision Making; Emotions; Gambling - psychology; Humans; Male; Middle Aged; Models, Psychological; Prospective Studies; Psychopathology; Reward; Simulation; Social Sciences; Young Adult; reward; psychopathy; affect; decision making; counterfactual reasoning
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.1609985113

Psychopathy is associated with persistent antisocial behavior and a striking lack of regret for the consequences of that behavior. Although explanatory models for psychopathy have largely focused on deficits in affective responsiveness, recent work indicates that aberrant value-based decision making may also play a role. On that basis, some have suggested that psychopathic individuals may be unable to effectively use prospective simulations to update action value estimates during cost–benefit decision making. However, the specific mechanisms linking valuation, affective deficits, and maladaptive decision making in psychopathy remain unclear. Using a counterfactual decision-making paradigm, we found that individuals who scored high on a measure of psychopathy were as ormore likely than individuals low on psychopathy to report negative affect in response to regret-inducing counterfactual outcomes. However, despite exhibiting intact affective regret sensitivity, they did not use prospective regret signals to guide choice behavior. In turn, diminished behavioral regret sensitivity predicted a higher number of prior incarcerations, and moderated the relationship between psychopathy and incarceration history. These findings raise the possibility that maladaptive decision making in psychopathic individuals is not a consequence of their inability to generate or experience negative emotions. Rather, antisocial behavior in psychopathy may be driven by a deficit in the generation of forward models that integrate information about rules, costs, and goals with stimulus value representations to promote adaptive behavior.