Movement and VIP Interneuron Activation Differentially Modulate Encoding in Mouse Auditory Cortex

• Published in: eNeuro Vol. 6; no. 5; p. ENEURO.0164-19.2019
• Main Authors: Bigelow, James, Morrill, Ryan J, Dekloe, Jefferson, Hasenstaub, Andrea R
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 01.09.2019
• Subjects: Acoustic Stimulation - methods; Action Potentials - physiology; Animals; Auditory Cortex - chemistry; Auditory Cortex - metabolism; Female; Gene Knock-In Techniques; Interneurons - chemistry; Interneurons - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Movement - physiology; New Research; Optogenetics - methods; Vasoactive Intestinal Peptide - analysis; Vasoactive Intestinal Peptide - metabolism; vasoactive intestinal peptide; information; locomotion; optogenetics; interneurons
• ISSN: 2373-2822; 2373-2822
• DOI: 10.1523/eneuro.0164-19.2019

Information processing in sensory cortex is highly sensitive to nonsensory variables such as anesthetic state, arousal, and task engagement. Recent work in mouse visual cortex suggests that evoked firing rates, stimulus-response mutual information, and encoding efficiency increase when animals are engaged in movement. A disinhibitory circuit appears central to this change: inhibitory neurons expressing vasoactive intestinal peptide (VIP) are activated during movement and disinhibit pyramidal cells by suppressing other inhibitory interneurons. Paradoxically, although movement activates a similar disinhibitory circuit in auditory cortex (ACtx), most ACtx studies report reduced spiking during movement. It is unclear whether the resulting changes in spike rates result in corresponding changes in stimulus-response mutual information. We examined ACtx responses evoked by tone cloud stimuli, in awake mice of both sexes, during spontaneous movement and still conditions. VIP cells were optogenetically activated on half of trials, permitting independent analysis of the consequences of movement and VIP activation, as well as their intersection. Movement decreased stimulus-related spike rates as well as mutual information and encoding efficiency. VIP interneuron activation tended to increase stimulus-evoked spike rates but not stimulus-response mutual information, thus reducing encoding efficiency. The intersection of movement and VIP activation was largely consistent with a linear combination of these main effects: VIP activation recovered movement-induced reduction in spike rates, but not information transfer.