Carbon Coating of Stents Has No Effect on Inflammatory Response to Primary Stent Deployment

• Published in: Angiology Vol. 53; no. 5; pp. 563 - 568
• Main Authors: Korkmaz, Mehmet Emin, Tayfun, Egemen, Müderrisoglu, Haldun, Yildirir, Aylin, Özin, Bülent, Uluçam, Melek, Turan, Münire
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Thousand Oaks, CA SAGE Publications 01.09.2002; Westminster; Sage Publications, Inc; SAGE PUBLICATIONS, INC
• Subjects: Adult; Aged; Angina Pectoris - therapy; Angina, Unstable - therapy; Angioplasty, Balloon, Coronary; Biological and medical sciences; C-Reactive Protein; Carbon; Care and treatment; Coated Materials, Biocompatible; Composition; Coronary Angiography; Coronary heart disease; Coronary Stenosis - therapy; Cytokines - blood; Data Interpretation, Statistical; Diseases of the cardiovascular system; Female; Fibrinogen - analysis; Humans; Inflammation; Inflammation - etiology; Interleukin-6 - blood; Leukocytes; Linear Models; Male; Medical sciences; Middle Aged; Physiological aspects; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Random Allocation; Risk Factors; Stainless Steel; Stent (Surgery); Stents - adverse effects; Human; Endoprosthesis; Prognosis; Coronary artery; Cytokine; Instrumentation therapy; Instrumental dilatation; Inflammation; Carbon; Coated material; Treatment; Fibrinogen; C reactive protein
• ISSN: 0003-3197; 1940-1574
• DOI: 10.1177/000331970205300510

The aim of this study was to investigate the effects of stent carbon coating on inflammatory response. The authors serially measured plasma concentrations of C-reactive protein (CRP), fibrinogen, and several cytokines (tumor necrosis factor, interleukin [IL]-1-β, IL-6, and IL-8) in patients with single-vessel coronary stenosis who underwent primary stent implantation. None of the subjects had inflammatory or infectious disease at the time of the procedure. Forty-six patients (38 males; mean age 55 ±9 years) were studied. Blood samples were collected before and at 2, 4, 6, 24, and 48 hours after stent implantation. Patients were randomly assigned 1 of 2 different stent types, an uncoated MAC (AMG® Raesfeld-Erle, Germany) (UC-MAC) or a carbon-coated MAC (CC-MAC) stent. Implantations were performed without predilatation, and stents were deployed at a maximum pressure of 6 atmospheres for 90 seconds. Of the 46 patients, 14 had stable, 27 had unstable, and 5 had atypical angina. According to ACC/AHA classification, 35 lesions (76.1 %) were type A, 10 (21.7%) were type B, and 1 (2.2%) was type C. Single stenosis of 28 left anterior descending, 12 circumflex, and 6 right coronary arteries were treated. Serum IL-6 increased in both the UC-MAC and CC-MAC groups, with concentra tions significantly elevated above baseline at 6 hours, and then decreasing after 24 hours (baseline, 6-hour, and 24-hour values = 3.1 ±2.3, 5.7 ±3.8, and 6.3 ±4.6 pg/mL, respectively, in UC-MAC; 3.7 ±2.6, 6.2 ±6.0, and 4.6 ±3.7 pg/mL, respectively, in CC-MAC [p=0.002]). Plasma fibrinogen, CRP, and leukocyte concentrations also increased in both groups over the 24 hours (p < 0.05). The elevations of IL-6, CRP, and fibrinogen were similar in the 2 groups. The percent increases in IL-6, fibrinogen, and CRP were not associated with stent length, size, or clinical presentation (all p>0.05). The results showed that stent implantation increases plasma IL-6, fibrinogen, and CRP concentrations, but carbon coating of the stent does not seem to affect this inflammatory response.