Posttranslational Modifications of RAS Proteins

The three human genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for...

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Bibliographic Details
Published inCold Spring Harbor perspectives in medicine Vol. 8; no. 11; p. a031484
Main Authors Ahearn, Ian, Zhou, Mo, Philips, Mark R.
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.11.2018
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Summary:The three human genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting. The enzymes that catalyze the various PTMs are potential targets for anti-RAS drug discovery. The PTMs of RAS proteins are the focus of this review.
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ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a031484