Increased cholesterol in plasma in a young man during experimental copper depletion

Signs of copper depletion were produced in a healthy man by an amount of dietary copper (0.83 mg/day) similar to that in some contemporary diets. Urinary and fecal loss of copper exceeded intake. Plasma copper, ceruloplasmin, and superoxide dismutase activity in erythrocytes decreased. Cholesterol i...

Full description

Saved in:
Bibliographic Details
Published inMetabolism, clinical and experimental Vol. 33; no. 12; p. 1112
Main Authors Klevay, L.M, Inman, L, Johnson, L.K, Lawler, M, Mahalko, J.R, Milne, D.B, Lukaski, H.C, Bolonchuk, W, Sandstead, H.H
Format Journal Article
LanguageEnglish
Published United States 01.12.1984
Subjects
Adult
Blood Cell Count
Ceruloplasmin - metabolism
CHOLESTEROL
Cholesterol - blood
COBRE
COLESTEROL
COPPER
Copper - blood
Copper - deficiency
Copper - urine
CUIVRE
DEFICIENCY DISEASES
ENFERMEDADES CARENCIALES
Erythrocytes - enzymology
Feces - analysis
HOMBRES
HOMME
Humans
MALADIE DE CARENCE
Male
MEN
NUTRIENT DEFICIENCIES
PLASMA
Superoxide Dismutase - blood
Online AccessGet more information

Cover

More Information
Summary:Signs of copper depletion were produced in a healthy man by an amount of dietary copper (0.83 mg/day) similar to that in some contemporary diets. Urinary and fecal loss of copper exceeded intake. Plasma copper, ceruloplasmin, and superoxide dismutase activity in erythrocytes decreased. Cholesterol in plasma increased, and hematologic indices were unchanged. Lipid metabolism may be a more sensitive index of copper nutriture than are changes in hematology. The findings support the hypothesis that inadequate copper nutriture or altered copper metabolism contributes to the occurrence of ischemic heart disease.
Bibliography:S30
8601017
ISSN:0026-0495
1532-8600
DOI:10.1016/0026-0495(84)90096-9