Pulmonary Hypertension Caused by Medial Hypertrophy Associated With Aortic Stenosis and Preductal Coarctation

• Published in: The Annals of thoracic surgery Vol. 64; no. 1; pp. 244 - 247
• Main Authors: Aota, Masaki, Nomoto, Shin-ichi, Yamaki, Shigeo, Ban, Toshihiko
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.1997; Elsevier Science
• Subjects: Aortic Coarctation - complications; aortic stenosis; Aortic Valve Stenosis - complications; Arterioles - pathology; Biological and medical sciences; Female; Humans; Hypertension, Pulmonary - etiology; Hypertension, Pulmonary - pathology; Hypertrophy; Infant; Infant, Newborn; Lung - blood supply; Lung - pathology; medial hypertrophy; Medical sciences; Persistent Fetal Circulation Syndrome; Pneumology; preductal coarctation; pulmonary hypertension; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; aortic stenosis; preductal coarctation; medial hypertrophy; pulmonary hypertension; Human; Aortic coarctation; Respiratory disease; Pathogenesis; Media; Stenosis; Cardiovascular disease; Congenital disease; Pulmonary hypertension; Arterial disease; Vascular disease; Case study; Pathology; Optical microscopy; Association; Malformation; Aorta; Aortic disease; Hypertrophy
• ISSN: 0003-4975; 1552-6259
• DOI: 10.1016/S0003-4975(97)00494-3

A 7-month-old female infant with aortic stenosis, preductal coarctation, and pulmonary hypertension underwent operation. Intraoperative lung biopsy revealed marked medial hypertrophy of the pulmonary arterioles. This histopathology is compatible with persistent pulmonary hypertension in the newborn. She is alive about 5 years after the operation, but pulmonary hypertension remains. The pathogenesis is discussed.