Improving in the Fasting, but Not the Postprandial, Glucose Level is Associated with Reduction of Plasma d-ROMs Level in Patients with Type 2 Diabetes

• Published in: Journal of Nippon Medical School Vol. 80; no. 3; pp. 200 - 210
• Main Authors: Ohara, Makoto, Watanabe, Kentaro, Suzuki, Tatsuya, Sekimizu, Ken-ichi, Motoyama, Masayuki, Ishii, Kazuhito, Sawai, Keisuke, Nakano, Hiroshi, Oba, Kenzo, Mizuno, Kyoichi
• Format: Journal Article
• Language: English
• Published: Japan The Medical Association of Nippon Medical School 2013
• Subjects: Adult; Aged; Aged, 80 and over; and postprandial glucose; Area Under Curve; Blood Glucose - metabolism; daily profile of plasma glucose; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; diacron-reactive oxygen metabolites; Fasting; Female; Humans; Male; Middle Aged; Oxidative Stress; Postprandial Period; Reactive Oxygen Species; Regression Analysis; type 2 diabetes
• ISSN: 1345-4676; 1347-3409
• DOI: 10.1272/jnms.80.200

Aims: This study aimed to evaluate the relationship between improvement of glucose metabolism and plasma levels of diacron-reactive oxygen metabolites (d-ROMs) in patients with type 2 diabetes. Methods: As the first daily profile, the plasma levels of glucose and d-ROMs were determined on admission. Then, after treatment to lower plasma glucose levels, the second daily profile of these levels was evaluated. Fasting plasma glucose (FPG), the total area under the curve (AUC) of the daily plasma glucose profile (AUCDP), the AUC of the postprandial plasma glucose levels (AUCPP), the AUC of the daily plasma d-ROMs profile (AUCd-ROMs), the coefficient of variation (CV) of plasma glucose (CVPG), and the mean amplitude of glycemic excursions (MAGE) were calculated. The relationship between the improvement of glucose metabolism and that of oxidative stress in patients with type 2 diabetes was evaluated. Results: The second determinations of FPG, AUCDP, AUCPP, MAGE, and AUCd-ROMs were significantly lower than those of the first determinations, but no significant difference was observed in CVPG. Linear regression analysis demonstrated significant associations between the changes in AUCd-ROMs and the changes in both FPG and AUCDP, whereas no significant association was observed between the change in AUCd-ROMs and the change in AUCPP, CVPG, or MAGE. Conclusions: This study has demonstrated that improvement of the FPG level, but not of the postprandial glucose level, is associated with a reduction of the plasma level of d-ROMs in patients with type 2 diabetes.