WTAP Expression Predicts Poor Prognosis in Malignant Glioma Patients

• Published in: Journal of molecular neuroscience Vol. 60; no. 2; pp. 131 - 136
• Main Authors: Xi, Zhuo, Xue, Yixue, Zheng, Jian, Liu, Xiaobai, Ma, Jun, Liu, Yunhui
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2016; Springer Nature B.V
• Subjects: Antibodies; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Biomedical and Life Sciences; Biomedicine; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Brain research; Cell Biology; Cell cycle; Epidermal growth factor; Female; Glioma - metabolism; Glioma - pathology; Hospitals; Humans; Male; Medical prognosis; Middle Aged; Nervous system; Neurochemistry; Neurology; Neurosciences; Neurosurgery; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Pallets; Pathology; Patients; Proteins; Proteomics; Radiation therapy; Survival Analysis; United States > US; China; Chicago Illinois; Immunohistochemistry; Survival analysis; WTAP; Gliomas
• ISSN: 0895-8696; 1559-1166; 1559-1166
• DOI: 10.1007/s12031-016-0788-6

Wilms’ tumor 1-associating protein (WTAP) interacts with the Wilms’ tumor 1 gene. Although originally classified as a tumor suppressor, WTAP was later found to be over-expressed in glioblastoma which is regarded as a grade IV astrocytoma. However, the expression in other glioma grades and the relationship between WTAP expression and the prognosis of glioma patients are still unknown. In this study, we investigated WTAP expression in 169 different types of glioma cases using western blot analysis and immunohistochemistry assay. Further, we evaluated the association of WTAP expression with clinicopathological characteristics using chi-square test and Spearman’s correlation test. We used univariate and multivariate Cox regression analyses to evaluate the independency of diferent WTAP expression. Then, the survival curves were calculated using the Kaplan-Meier method. Results showed that WTAP was over-expressed in glioma tissues, and the expression was closely correlated with glioma grade. Moreover, high WTAP expression was correlated with poor postoperative survival in glioma patients. WTAP may serve as a novel prognostic marker.