Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery
Despite drug formulation improving circulation times and targeting, efficacy is stymied by inadequate penetration into and retention within target tissues. This review highlights the barriers restricting delivery to the connective tissue interstitium, lymphatics, and lymph nodes as well as advances...
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| Published in | Current opinion in chemical engineering Vol. 7; pp. 65 - 74 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
01.02.2015
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Despite drug formulation improving circulation times and targeting, efficacy is stymied by inadequate penetration into and retention within target tissues. This review highlights the barriers restricting delivery to the connective tissue interstitium, lymphatics, and lymph nodes as well as advances in engineering drug carriers to overcome these delivery challenges. Three-dimensional tissue physiology is discussed in the context of providing material design principles for delivery to these tissues; in particular the influence of interstitial and lymphatic flows as well as differential permeabilities of the blood and lymphatic capillaries. Key examples of materials with different characteristics developed to overcome these transport barriers are discussed as well as potential areas for further development. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 2211-3398 2211-3398 |
| DOI: | 10.1016/j.coche.2014.11.003 |