Modeling drug exposure in rodents using e-cigarettes and other electronic nicotine delivery systems

• Published in: Journal of neuroscience methods Vol. 330; p. 108458
• Main Authors: Miliano, Cristina, Scott, E. Reilly, Murdaugh, Laura B., Gnatowski, Emma R., Faunce, Christine L., Anderson, Megan S., Reyes, Malissa M., Gregus, Ann M., Buczynski, Matthew W.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2020
• Subjects: Animals; Central Nervous System Stimulants - administration & dosage; Central Nervous System Stimulants - adverse effects; Disease Models, Animal; E-cigarette; Electronic Nicotine Delivery Systems; ENDS; Mouse; Nicotine; Nicotine - administration & dosage; Nicotine - adverse effects; Peripheral Nervous System Agents - administration & dosage; Peripheral Nervous System Agents - adverse effects; Rat; Rats; Rodentia; Vaping; Vaping - adverse effects; ENDS; Vaping; Mouse; Rat; E-cigarette; Nicotine
• ISSN: 0165-0270; 1872-678X; 1872-678X
• DOI: 10.1016/j.jneumeth.2019.108458

•Electronic nicotine delivery devices (ENDS) replacing tobacco use in youth populations.•Advances in ENDS technology facilitates preclinical inhalation exposure paradigms.•Chronic nicotine exposure by ENDS in rodents provide evidence of detrimental health effects.•ENDS evaluate addictive properties of other drugs of abuse in rodent via inhalation. Smoking tobacco products is the leading cause of preventable death worldwide. Coordinated efforts have successfully reduced tobacco cigarette smoking in the United States; however, electronic cigarettes (e-cigarette) and other electronic nicotine delivery systems (ENDS) recently have replaced traditional cigarettes for many users. While the clinical risks associated with long-term ENDS use remain unclear, advancements in preclinical rodent models will enhance our understanding of their overall health effects. This review examines the peripheral and central effects of ENDS-mediated exposure to nicotine and other drugs of abuse in rodents and evaluates current techniques for implementing ENDS in preclinical research.