‘Normal’ semantic–phonemic fluency discrepancy in Alzheimer's disease? A meta-analytic study

• Published in: Cortex Vol. 46; no. 5; pp. 595 - 601
• Main Authors: Laws, Keith R., Duncan, Amy, Gale, Tim M.
• Format: Journal Article
• Language: English
• Published: Italy Elsevier Srl 01.05.2010
• Subjects: Age Factors; Aged; Alzheimer Disease - complications; Cognitive reserve; Dementia; Educational Status; Female; Fluency; Humans; Language Disorders - complications; Language Tests; Male; Neuropsychological Tests; Phonetics; Picture naming; Regression Analysis; Semantics; Severity of Illness Index; Sex Characteristics; Sex differences; Speech Disorders - complications; Cognitive reserve; Fluency; Sex differences; Picture naming; Dementia

In a meta-analysis of 135 studies involving 6000 patients with Alzheimer's disease (AD) and 6057 healthy controls, we examined the relative degree of semantic and phonemic fluency impairment in AD patients. The effect size for semantic fluency ( d = 2.10: 95%CI 2.22–1.97) was significantly larg...