Polycyclic aromatic hydrocarbons exposure, oxidative stress, and asthma in children

• Published in: International archives of occupational and environmental health Vol. 90; no. 3; pp. 297 - 303
• Main Authors: Wang, I-Jen, Karmaus, Wilfried J. J., Yang, Chen-Chang
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2017; Springer Nature B.V
• Subjects: Asthma; Asthma - epidemiology; Asthma - etiology; Biomarkers - urine; Case-Control Studies; Child; Child, Preschool; Earth and Environmental Science; Environment; Environmental Exposure - adverse effects; Environmental Health; Female; Health risk assessment; Human exposure; Humans; Immunoglobulin E - blood; Male; Occupational Medicine/Industrial Medicine; Original Article; Oxidative Stress; Pediatrics; Polycyclic aromatic hydrocarbons; Polycyclic Aromatic Hydrocarbons - toxicity; Rehabilitation; Socioeconomic Factors; Taiwan - epidemiology; Oxidative stress; PAHs; IgE levels; 8OHdG; Asthma
• ISSN: 0340-0131; 1432-1246
• DOI: 10.1007/s00420-017-1198-y

Purpose Polycyclic aromatic hydrocarbons (PAHs) are known for their carcinogenic and teratogenic properties. However, little is known about the effect of PAH on our immune and respiratory systems. Hence, we investigated associations (1) between PAH exposure and IgE levels and asthma in children and (2) between PAH exposure and the oxidative stress marker 8OHdG potentially involved in disease pathogenesis stratifying by (3) sex-based differences. Methods A total of 453 kindergarten children were recruited and provided samples. Urine biomarker of PAH exposure (1-OHP levels) was measured by UPLC-MS/MS and a marker of oxidative stress (8OHdG) was measured by ELISA. Serum IgE were assessed and information on asthma was collected. Associations between 1-OHP levels, 8OHdG, IgE and asthma were analyzed by multivariate linear and logistic regression. A mediation analysis was conducted to evaluate whether the risk of increased IgE and asthma related to PAH exposure is explained by 8OHdG changes. Results Urine 1-OHP levels were positively related to 8OHdG levels (per ln-unit: β  = 0.30kU/l, p  = 0.002). Similar results were also found for 1-OHP levels with IgE levels (per ln-unit: β  = 0.27 kU/l, p  = 0.027). 1-OHP levels (per ln-unit) were significantly associated with asthma, with an OR (95% CI) of 1.42 (1.18–1.70). In addition, 1-OHP levels were associated with asthma. It is estimated that 35% of the effect of PAH exposure on asthma is mediated by 8OHdG levels. Conclusion Exposure to PAH may enhance oxidative stress and may induce asthma. The effect of PAH exposure on asthma may be mediated by oxidative stress.