Peripheral Neuropathy Associated With Antiglutamic Acid Decarboxylase Antibodies

Abstract Autoantibodies to glutamic acid decarboxylase are found in some rare neurological diseases. However, acute peripheral neuropathy associated with antiglutamic acid decarboxylase autoimmunity has not been reported previously. Here we report a case of a patient who presented with acute cranial...

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Published inPediatric neurology Vol. 48; no. 5; pp. 403 - 406
Main Authors Saltk, Sema, MD, Türkeş, Muzaffer, MD, Tüzün, Erdem, MD, Cakr, Arif, MD, Ulusoy, Canan, MSc
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2013
Subjects
Abducens Nerve Diseases - etiology
Abducens Nerve Diseases - physiopathology
Adolescent
Autoantibodies - immunology
Autoimmune Diseases of the Nervous System - complications
Autoimmune Diseases of the Nervous System - immunology
Autoimmune Diseases of the Nervous System - therapy
Diplopia - etiology
Diplopia - physiopathology
Electromyography
Glutamate Decarboxylase - immunology
Humans
Immunoglobulins, Intravenous
Infant
Male
Muscle Weakness - etiology
Muscle Weakness - physiopathology
Neural Conduction - physiology
Neurologic Examination
Neurology
Pediatrics
Peripheral Nerves - physiopathology
Peripheral Nervous System Diseases - complications
Peripheral Nervous System Diseases - immunology
Peripheral Nervous System Diseases - therapy
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Summary:Abstract Autoantibodies to glutamic acid decarboxylase are found in some rare neurological diseases. However, acute peripheral neuropathy associated with antiglutamic acid decarboxylase autoimmunity has not been reported previously. Here we report a case of a patient who presented with acute cranial and peripheral neuropathy in association with the presence of serum antiglutamic acid decarboxylase antibodies. A 13-year-old boy was admitted to our pediatric neurology clinic with diplopia due to sixth cranial nerve palsy and ascending motor weakness in all extremities. The nerve conduction studies showed bilateral motor and sensory demyelinating neuropathy. Full recovery was achieved following intravenous immunoglobulin treatment. Glutamic acid decarboxylase autoimmunity–associated neurological diseases spectrum may also include acute demyelinating peripheral neuropathy.
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ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2012.12.031