Determinants of Risk Factors for Renal Impairment among HIV-Infected Patients Treated with Tenofovir Disoproxil Fumarate-Based Antiretroviral Regimen in Southern Vietnam

• Published in: BioMed research international Vol. 2020; no. 2020; pp. 1 - 9
• Main Authors: Phan, Lan T., Ly, Hong, Linh, Hoang Thuy, Nguyen, Khai T, Vu, Huy Q., Nguyen, Hai D., Hoang, Cuong Q., Tat, Thang D
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; Hindawi Limited
• Subjects: Acquired immune deficiency syndrome; Adult; Age; AIDS; Anti-Retroviral Agents - administration & dosage; Anti-Retroviral Agents - adverse effects; Antiretroviral agents; Antiretroviral drugs; Body mass index; Correlation analysis; Creatinine; Cross-Sectional Studies; Demographics; Disease transmission; Epidermal growth factor receptors; Female; Glomerular filtration rate; Hemoglobin; Hepatitis; HIV; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV-1; Hospitals; Human immunodeficiency virus; Humans; Impairment; Infections; Isoniazid; Kidney diseases; Kidney Diseases - chemically induced; Kidney Diseases - epidemiology; Kidneys; Longitudinal studies; Male; Middle Aged; Multivariate analysis; Patients; Prevalence; Regression analysis; Renal function; Risk analysis; Risk Factors; Serological tests; Statistical analysis; Tenofovir; Tenofovir - administration & dosage; Tenofovir - adverse effects; Vietnam - epidemiology; Vietnam; United States > US
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2020/7650104

Background. The situation of renal impairment among HIV-infected patients treated with TDF-based antiretroviral (ARV) regimen greater than 3 years is little known when TDF use has been promptly increasing in Vietnam. Methods. We analyse demographic and clinical data from a cross-sectional survey of 400 HIV-infected patients aged ≥18 years, who were treatment-naive or switched TDF regimen within over 3 years between November 2018 and March 2019. Serological tests for serum creatinine, ALT, and AST were performed. Renal impairment was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. Multivariate regression analyses were used to explore the risk factors associated with renal impairment. Results. At the baseline, 7.8% of respondents had estimated glomerular filtration rate (eGFR) of 30–59 mL/min/1.73 m2 and 0.8% had eGFR of 15–29 mL/min/1.73 m2, out of 34 (8.5%) of participants who had renal impairment. Multivariate analysis showed that participants who had preexposure to isoniazid (adjusted PR [aPR] = 0.35 Cl: 0.14–0.91) compared with nonexposure to isoniazid who had a BMI from 18.5 up to 25 kg/m2 (aPR = 0.31 Cl: 0.15–0.62) compared with BMI below 18.5 kg/m2 were less likely to suffer from renal impairment. Patients aged greater than 60 years (aPR = 26.75, 95% Cl: 3.38–211.62) compared with those aged 20–29 years were more likely to have increased risk of renal impairment. Conclusion. Our findings underscore the need for longitudinal studies to assess the influence of TDF on maintaining the low prevalence of renal impairment among HIV-infected patients in Vietnam.