Iron-promoted C-C bond formation in the total synthesis of natural products and drugs

Covering: up to 2015 Iron salts are inexpensive and almost innocuous; they are thus the promoters of choice, even in stoichiometric amounts, for the formation of carbon-carbon bonds in the backbone of complex molecules. This review encompasses the key role of iron complexes in the total synthesis of...

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Published inNatural product reports Vol. 32; no. 11; pp. 1541 - 1555
Main Authors Legros, Julien, Figadère, Bruno
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 01.01.2015
Subjects
Biological Products - chemical synthesis
Biological Products - chemistry
Carbon - chemistry
Chemical Sciences
Iron - chemistry
Molecular Structure
Pharmaceutical Preparations - chemical synthesis
Pharmaceutical Preparations - chemistry
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Summary:Covering: up to 2015 Iron salts are inexpensive and almost innocuous; they are thus the promoters of choice, even in stoichiometric amounts, for the formation of carbon-carbon bonds in the backbone of complex molecules. This review encompasses the key role of iron complexes in the total synthesis of some natural products or pharmacologically important compounds. Iron complexes can be used in catalytic or stoichiometric quantities to form C-C bonds for building the backbone of complex molecules. A review of their use in the total synthesis of natural products or pharmacologically important compounds is presented.
Bibliography:Julien Legros was born in 1974 and educated at the Universities Paris East, and then Paris South-Faculty of Pharmacy where he received his PhD under the guidance of Dr D. Bonnet-Delpon and J.-P. Bégué (2002). After an Alexander von Humboldt post-doctoral position on iron catalysis with Prof. C. Bolm at the RWTH University (Aachen, Germany), he got a permanent position at the CNRS in 2004 (Univ Paris South-Faculty of Pharmacy) and then moved to the University of Rouen in 2011. Julien Legros is involved in synthetic methodology in non-conventional media (flow microreactors, hyperbaric conditions, fluorous solvents).
Bruno Figadère, born in 1960, was educated in Paris (University Pierre et Marie Curie) where he received his PhD under Dr G. Cahiez leadership. After a post-doctoral position at the University of California at Riverside with Prof W. H. Okamura (1988-1990) he got a permanent position at the CNRS and since then works at University of Paris Sud-Faculty of Pharmacy. He is currently director of the BioCIS laboratory. Bruno Figadère is involved in the chemistry of natural products, especially in total synthesis, pharmacomodulation and characterisation of new bioactive compounds from different origins.
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ISSN:0265-0568
1460-4752
DOI:10.1039/c5np00059a