Influence of Skull Modeling Approaches on EEG Source Localization

• Published in: Brain topography Vol. 27; no. 1; pp. 95 - 111
• Main Authors: Montes-Restrepo, Victoria, van Mierlo, Pieter, Strobbe, Gregor, Staelens, Steven, Vandenberghe, Stefaan, Hallez, Hans
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.01.2014; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Bone (spongy); Brain - physiology; Electroencephalography; Humans; Magnetic Resonance Imaging; Models, Neurological; Neurology; Neurosciences; Original Paper; Psychiatry; Skull - anatomy & histology; Tomography, X-Ray Computed; Skull modeling; EEG source localization; Realistic head model; Finite difference method
• ISSN: 0896-0267; 1573-6792; 1573-6792
• DOI: 10.1007/s10548-013-0313-y

Electroencephalographic source localization (ESL) relies on an accurate model representing the human head for the computation of the forward solution. In this head model, the skull is of utmost importance due to its complex geometry and low conductivity compared to the other tissues inside the head. We investigated the influence of using different skull modeling approaches on ESL. These approaches, consisting in skull conductivity and geometry modeling simplifications, make use of X-ray computed tomography (CT) and magnetic resonance (MR) images to generate seven different head models. A head model with an accurately segmented skull from CT images, including spongy and compact bone compartments as well as some air-filled cavities, was used as the reference model. EEG simulations were performed for a configuration of 32 and 128 electrodes, and for both noiseless and noisy data. The results show that skull geometry simplifications have a larger effect on ESL than those of the conductivity modeling. This suggests that accurate skull modeling is important in order to achieve reliable results for ESL that are useful in a clinical environment. We recommend the following guidelines to be taken into account for skull modeling in the generation of subject-specific head models: (i) If CT images are available, i.e., if the geometry of the skull and its different tissue types can be accurately segmented, the conductivity should be modeled as isotropic heterogeneous. The spongy bone might be segmented as an erosion of the compact bone; (ii) when only MR images are available, the skull base should be represented as accurately as possible and the conductivity can be modeled as isotropic heterogeneous, segmenting the spongy bone directly from the MR image; (iii) a large number of EEG electrodes should be used to obtain high spatial sampling, which reduces the localization errors at realistic noise levels.