Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts

• Published in: American journal of respiratory cell and molecular biology Vol. 61; no. 5; pp. 597 - 606
• Main Authors: Hamanaka, Robert B, O'Leary, Erin M, Witt, Leah J, Tian, Yufeng, Gökalp, Gizem A, Meliton, Angelo Y, Dulin, Nickolai O, Mutlu, Gökhan M
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.11.2019
• Subjects: Amino acids; Cell Differentiation; Cells, Cultured; Collagen; Collagen - metabolism; Fibroblasts; Fibroblasts - metabolism; Glutaminase - metabolism; Glutamine; Glutamine - metabolism; Humans; Intermediates; Ketoglutaric acid; Lung - pathology; Metabolism; Mitochondria; Myofibroblasts - metabolism; Original Research; Oxidation; Protein biosynthesis; Protein synthesis; Protein turnover; Studies; Transforming Growth Factor beta - metabolism; fibroblast; glutamine; cellular metabolism; pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is characterized by the transforming growth factor (TGF)-β-dependent differentiation of lung fibroblasts into myofibroblasts, leading to excessive deposition of extracellular matrix proteins, which distort lung architecture and function. Metabolic reprogramming in...